WGS – Large Genomes

The UM DNA Sequencing Core can sequence entire genomes from human, mouse, rat, etc. Typically, this would be done in order to spot variants (for example causative variants for interesting phenotypes) when compared to the reference sequence. Because of the large size of these genomes, a substantial amount of sequencing is required in order to achieve reasonable coverage. Consequently, the Illumina sequencing options, below, are the most common choice.

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