WGS – Large Genomes


The UM DNA Sequencing Core can sequence entire genomes from human, mouse, rat, etc. Typically, this would be done in order to spot variants (for example causative variants for interesting phenotypes) when compared to the reference sequence. Because of the large size of these genomes, a substantial amount of sequence is required in order achieve reasonable coverage. Consequently, the Illumina sequencing option, below, is the most common choice. If, however, you are interested in studying long-range structural variants, or you have a de novo sequencing project (one for which no reference genome exists) you may want to consider the PacBio sequencer. That instrument provides excellent read lengths, which provide for better difficult genome assemblies.

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