Mass Spectrometry Instrumentation

Orbitrap Fusion Lumos mass spectrometer (Thermo Scientific) coupled to a UPLC (Waters)

  • Improved accuracy for relative quantitation (TMT, SILAC)
  • Identification of more low-level proteins with better accuracy
  • Used to analyze highly complex samples
  • Sub ppm mass accuracy

 

Q-Exactive mass spectrometer coupled to UPLC (Waters):

  • High throughput screening (post-translational modifications)
  • Protein ID
  • Label-free quantitation by spectral counting
  • Targeted quantitative proteomics (PRM)

 

Orbitrap Velos mass spectrometer (ThermoScientific)

  • Protein ID
  • Qualitative protein profiling

 

Ultraflextreme MALDI-TOF/TOF mass spectrometer (Bruker):

  • Protein intact molecular weight analysis by MALDI-TOF and more

 

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