BRCF Research Reactivation

Updated 6/16/2020: As part of the Medical School Research Reactivation Process guidelines, a wave 3 ramp-up will begin on Thursday, June 18th for labs and staff who conduct research within Med Sci I, II, Rogel Cancer Center, Brehm, Kellogg, NCRC 20, NCRC 26, NCRC 520, ARF, Buhl and NIB. Cores located within these approved buildings, along with BSRB, LSI, MSRB 1, 2, 3, MBNI, NCRC 14, 23, 35, 36, 60, 90 and NCRC 26 VIVARIUM, are participating in this next ramp-up.

*Labs and staff who conduct research within buildings that haven’t ramped up are unable to access these approved buildings.

 

Sample Drop-off & Pick-up Procedure Between Research Laboratory and Core Laboratory for Researchers Outside of Core Laboratory Buildings
  1. On the day of sample drop-off or pick-up, research laboratory staff members must be screened at their home building location and obtain a sticker for the day documenting successful health screening clearance.
  2. Coordinate a meeting time between research laboratory staff members and core laboratory staff members at lobby screening location within core laboratory buildings.
  3. Arrive at the lobby of core laboratory building and show greeter health screening clearance sticker from home building location. Inform greeters of sample transactions to occur.
  4. Complete transactions while maintaining social distancing guidelines between staff members.
  5. Research laboratory staff members and core laboratory members will each return to their laboratory

Alternatively, some Cores are participating in sample drop-off or pick-up outside of the buildings at agreed-upon locations. Please contact Core Directors for availability and details.

Core Laboratory Shared Instrumentation Access Procedure for Researchers Outside of Core Laboratory Buildings
  1. Research laboratory members must create an instrument reservation in MiCores at least 24 hours in advance. (same-day reservations cannot be accommodated during the ramp-up)
  2. At the end of each business day, core laboratory staff will provide a list of names to the core laboratory building greeter of research laboratory staff with reservations for the next business day.
  3. The research laboratory staff member must be screened at their home building location and obtain a sticker for the day documenting successful health screening clearance.
  4. The core laboratory building greeter will be shown the health screening clearance sticker and will cross-check research laboratory staff’s UM ID against the list of approved users for the day.


Advanced Genomics Core

As part of Phase 1 Wave 3 of the Medical School Research Reactivation Process, research ramp-up included the Advanced Genomics Core located within building 14 of the North Campus Research Complex (NCRC).

As research across campus returns, it is important to understand that in response to COVID-19, AGC operations are required to change in order to bring our employees back to the lab safely. We have updated some of our policies and procedures to reflect the recommended social distancing guidelines.

Standard sample submissions resumed Monday, June 15th. For the most up-to-date sample drop-off instructions, see this page.

Please note that unused samples can no longer be retrieved. If needed, please submit an aliquot only.

Thank you all for your patience and cooperation as we take these initial steps in reopening AGC operations at the University of Michigan. Please contact us with any questions.

Biomedical Research Store

Biomedical Research Store locations within BSRB, LSI, NCRC, and MSRB II have been approved to reopen for labs and staff who conduct research within these approved buildings only.

As we start up research projects again, it is important to understand that due to mandatory social distancing guidelines, core operations will be different than in the past. New operational guidelines are outlined below, and we are happy to answer any questions you may have.

Biomedical Research Store Operating Procedures Beginning Monday, June 8th:

  • Regular hours will be Monday – Friday from 10:00 am to 4:00 pm.
  • Customers will utilize a stock product pick-up form that will be available on our website to order products. After the pick-up form and order are submitted to the BRS, the customer will receive an email with a receipt, product availability, and an estimated product pick-up time.
  • To maintain social distancing, the store door will remain closed and we will be utilizing a table or cart in the doorway/hallway to allow customers to pick-up their orders on a scheduled basis. Staff will be inside the store processing orders.
  • We will accept Special Orders, however, there may be delays depending on product inventory and volume of the order placed.
  • NCRC Customers will utilize the delivery form to procure any items stock and special from The Biomedical Research Store. We will offer an afternoon (by 4:00 PM) delivery daily as needed. The cut-off time to place delivery orders is 1:45 pm. Customers will not be required to sign receipts and there will be no on-site pickup.

Thank you all for your patience and cooperation as we take these first steps in reopening research at the University of Michigan. If you have any questions, please contact bmrs1@umich.edu.

Epigenomics Core

The Epigenomics Core has been approved to reopen for labs and staff who conduct research within MSRB.

As we start up research projects again, it is important to understand that due to mandatory social distancing guidelines, core operations will be different than in the past. New operational guidelines are outlined below, and we are happy to answer any questions you may have.

Ramp-Up Procedures for the Epigenomics Core

Customer sample drop-off:

  • Customers will need to schedule a time they are bringing their samples to the core (this will be added to the website, the iLabs submission page).
  • Customers will not be allowed in the lab.
  • Samples will be left on the red cart next to the Epigenomics Core. A box of ice will be put there when we know samples are coming. Specific instructions will be given to the customers for the labeling of samples.

Thank you all for your patience and cooperation as we take these first steps in reopening research at the University of Michigan. If you have any questions, please contact me at clalance@umich.edu.

Flow Cytometry Core

All Flow Cytometry Core locations have been approved to reopen for labs and staff who conduct research within these approved buildings.

As we start-up research projects again, it is important to understand that due to mandatory social distancing guidelines, core operations will be different than in the past. New operational guidelines are outlined below, and we are happy to answer any questions you may have.

Ramp-Up Procedures for the Flow Cytometry Core

The MiCores calendar has already been opened to accept appointment requests, however, there are a few things to keep in mind:

  • Flow Cytometry Core operations are currently planned for staff operation Monday-Friday, 9:00 AM – 5:00 PM.
    • Should usage necessitate increased hours prior to opening the other facilities, we will examine the possibility of staffing on the weekend.
  • The Flow Core will be operating on a limited operating day, from 6:00 AM – 6:00 PM.
    • During the initial ramp-up, building access is for building occupants only. Others will not be given access to the building, per Medical School/UMOR decision.
    • While self-assist users are welcome to use the core as per normal, we do not control access to the building.
    • Access to the Flow Core is restricted to a single entrance. As there will likely be lines for entrance and screening, you should plan to arrive accordingly.
  • Self-Assist (SA) Operators will be given access to the lab, however,
    • As we must stagger the number of individuals in the lab at any given time, SA appointments are no longer auto-approved and must go through the standard manual approval process.
    • SA users must wear masks, gloves, and gowns/coats in the lab at all times.
    • SA users will be required to wipe down the workstation with ethanol upon finishing.
  • Technician-assisted investigators will no longer be allowed to enter the lab.
  • Samples will be dropped off at the station located outside the lab door.
  • Sample tubes must be labeled numerically (1,2,3,…) and accompanied with a sheet identifying the tubes.
  • Samples must include negative (unstained) and single positive control samples (no exceptions).
  • While you will not be allowed into the lab during the experiment, if you include an email in the “Event Notes” section of the MiCore appointment request, we will send you the TeamViewer remote desktop login information. With this software, you will be able to monitor the experiment, speak to the operating technician, and even take control to draw gates if desired.
  • Data will be emailed to the user in PDF (or requested alternative) format.
  • Sorted samples will be placed at the drop-off location for pickup.
  • For the time being, hands-on training will be unavailable as it can not be performed under the mandated social distancing requirements.

Thank you all for your patience and cooperation as we take these first steps in reopening research at the University of Michigan. If you have any questions, please contact me at davadams@umich.edu.

Metabolomics Core

The Metabolomics Core has been approved to reopen for labs and staff who conduct research at Brehm.

As we start up research projects again, it is important to understand that due to mandatory social distancing guidelines, core operations will be different than in the past. New operational guidelines are outlined below, and we are happy to answer any questions you may have.

Ramp-Up Procedures for the Metabolomics Core

At this time, the Metabolomics core will be open select hours on Tuesday’s and Wednesday’s for customer pick-ups and drop-offs. Future availability will be determined as needed.

For In-Building Customers

  • Pre-arranged drop-off will need to be made with Kari Bonds, Metabolomics Core Sample Coordinator
  • Customers should email Kari beforehand to let her know they are dropping off samples, and give an approximate time
  • Kari will have a table outside of her office where samples will be dropped off (samples should be brought in a styrofoam cooler, on dry ice) and she will check regularly to put samples into -80 C storage

For Out-of-Building Customers:

  • Pre-arranged drop-off/pick-up will be made at the back (west) side of the building
  • Customers will coordinate a time to meet Kari Bonds via email
  • On the day of sample drop-off or pick-up, research laboratory staff members must be screened at their home building location and obtain a sticker for the day documenting successful health screening clearance

Additional Customer Guidelines:

  • If customers are entering the building, they will arrive at the lobby of the core laboratory building and show greeter health screening clearance stickers from home building locations. Inform greeters of sample transactions to occur
  • Customers and Kari (or other lab staff as designated) will complete transactions utilizing a cart while maintaining social distancing guidelines
  • Research laboratory staff members and core laboratory members will each return to their laboratory

Microscopy Core

New Microscopy Core Usage Policies During COVID-19

In order to ensure public health, while still advancing and supporting imaging research, the Microscopy Core has instituted a number of new user interaction and microscope use policies (below). We understand that these policies create some inconvenience, but we have tried to strike a balance between continued ease of use and maintaining a healthy environment within a publicly shared facility. Please contact us with any questions that you may have.

Useful links that we will use to interact with you:

New User Consultations

All consultations with core staff will now be performed remotely via BlueJeans or telephone. When requesting a consultation, please include a few dates and times when you are available as well as how we should contact you. 

Sample Preparation Services (for LM or EM)

Sample prep services will proceed largely as always:

  • Schedule a time with Core staff to pick up any reagents needed for your experiment (e.g. fixative)
  • When your sample is ready for processing, please tell us in advance when you will be coming to drop-off your sample
  • EM samples should be dropped off in the chemical fume hood in the EM lab area (A816, follow signs). LM samples should be dropped off in the deli fridge just inside our back door (across from A841, follow signs).

Some EM sample prep steps where we previously trained users will now be performed directly by core staff in order to limit close interactions.

Image Analysis Training or Service

Image analysis consultations will now be performed remotely:

  • Please share with us in advance a few representative datasets via Google Drive (not MBox)
  • Tell us some times when you can be available at your U-M computer to discuss the data, acquisition settings, and goals (what you are trying to do/measure/render).
  • At the scheduled time, we will call you on the phone and we may connect to your computer using Bomgar to show you how to do the analysis using freeware that we will install on your computer. You may also decide that we should do the analysis for you, on a fee-for-service basis.

Microscope Training and Use

Microscope training and use procedures have changed substantially. We realize that some of the new precautions are inconvenient, but please be patient. Trainings are charged as a one-time fee, so if a training takes longer than before, you will not be charged extra. Because our rooms are very small, no more than one user will be allowed in a microscope room at any one time. You can no longer bring a lab mate, and we can now train only one person at once.

There are now two parts to microscope training:

  1. Before coming to the core, you will watch some short online videos that depict ‘generic’ aspects of microscope use: https://brcf.medicine.umich.edu/cores/microscopy/outreach/
  2. Core staff will schedule a time with you when you can come and work on the microscope with your sample. We will not sit with you. You will sit by yourself, and we will connect to the microscope acquisition computer remotely using Bomgar to guide you on how to optimally set the acquisition settings for your sample. Each scope room will also contain a phone with speaker and a webcam that you can use to point at the microscope etc. if we need a closer look at something.

Policies and Procedures regarding microscope use:

  • Arrive at the core 30 min AFTER the start of your scheduled time as reserved on the iLabs calendar. The purpose of this delay is to allow sufficient time for room air exchange between users, since our rooms are very small. Based on measured airflow rates, a 30 min delay allows for 5 air exchanges between users, which should reduce aerosols >10x. Instrument use time is not billed from the calendar, so you will not be charged for this delay. Please exit the microscope at the end of your scheduled time as always.
  • When you arrive with your sample, the core staff member working with you will briefly meet you in our cell culture room (A852, to the right of our main entrance door) to inspect your sample. Please place your sample on the bench so that we can look at it and then stay +2 meters away.
  • LM Users: Once we agree that the mounting of the sample is OK, we will show you which microscope to use. We will then go back to our office and connect to the microscope computer remotely, while you sit at the microscope with your sample. All further training will occur remotely via Bomgar.
  • EM Users: Core staff will take your sample and load it into the microscope. You may then enter the microscope room. We will go back to our office and connect to the microscope computer remotely, while you sit at the microscope with your sample. All further training will occur remotely via Bomgar.
  • Sanitation Protocol: Eyes commonly touch the microscope eyepieces during use. Before you look in the microscope, cover the eyepieces with the Saran wrap provided and attach it with a rubber band. Dispose of the Saran wrap and rubber bands when you are finished. You will also find a spray bottle of 70% EtOH and paper towels. Please spray EtOH onto some paper towel, and then gently wipe down all surfaces and parts of the microscope, keyboard, and phone (if you used it). Cleaning may not be completely effective, so we highly recommend that you also wear lab gloves and lab coat (if available) throughout your use of the microscope (we do not provide PPE).

Proteomics & Peptide Synthesis Core

The Proteomics & Peptide Synthesis Core has been approved to reopen for labs and staff who conduct research within MSRB. Clients from other buildings that are already open should email the Core at hremmer@umich.edu for access to the Core.

As we start up research projects again, it is important to understand that due to mandatory social distancing guidelines, core operations will be different than in the past. New operational guidelines are outlined below, and we are happy to answer any questions you may have.

Ramp-Up Procedures for the Proteomics & Peptide Synthesis Core

In the ramp-up phase, we will be present in the wet lab on Tuesdays and Thursdays, 10:00 am-1:00 pm, to accept samples.  We will follow the EHS checklist for Restarting Research Activities and the Cleaning and Disinfection Protocol for the Prevention of COVID-19 in U-M Laboratory Facilities. The individual working in the lab space will wear gloves and a mask and ensure social distancing of at least 6 feet. 

The sample submission process for proteomics services is as follows: 

  1. To initiate sample submission please email Dr. Henriette Remmer at hremmer@umich.edu to register your samples, ask questions and submit the request form.
  2. You will get an appointment to bring your sample to the Core. This appointment will be Tuesdays or Thursdays between 10:00 AM and 1:00 PM.
  3. You will enter through the Proteomics Core door in lab C568 MSRB II and only proceed up to the tape-marking on the floor. Please place your samples in the sample drop off box to your right and step back towards the door. The client will leave the lab and we will subsequently approach the sample box to take the samples and start processing.

For peptide synthesis services: While peptide orders are handled completely electronically, appointments will be necessary for peptide pick-up. When you enter the Proteomics Core, stay in the doorway, the peptide will be taken out of the freezer and placed in the peptide synthesis box by core personnel. Then we step back and you can pick up the peptide. Any questions will be handled electronically.

Thank you all for your patience and cooperation as we take these first steps in reopening research at the University of Michigan. If you have any questions, please contact me at hremmer@umich.edu.

Transgenic Animal Model Core

The Transgenic Animal Model Core has been approved to reopen for labs and staff who conduct research within approved buildings.

As we start up research projects again, it is important to understand that due to mandatory social distancing guidelines, core operations will be different than in the past. New operational guidelines are outlined below, and we are happy to answer any questions you may have.

Ramp-Up Procedures for the Transgenic Core

Sample Pick-up/Drop-off

For all sample pick-ups and drop-offs, core staff will make appointments with Core users in buildings open for research or those with approved COVID-19 research. During sample handoff materials social distancing of at least 6 feet will be observed.

Thank you all for your patience and cooperation as we take these first steps in reopening research at the University of Michigan. If you have any questions, please contact me at tsaunder@umich.edu.

Vector Core

The Vector Core has been approved to reopen to support labs and staff that conduct research within these approved buildings.

As we start up research projects again, it is important to understand that due to mandatory social distancing guidelines, Vector Core operations will be different than in the past. New operational guidelines are outlined below, and we are happy to answer any questions you may have.

Ramp-Up Procedures for the Vector Core

For all customer pick-ups and drop-offs, core staff will only be available from 11:00 AM to 1:00 PM, daily. 

For in-building customers:

Plasmids orders: 

  • Racks will be available at our lab office “greeting desk” for customers to drop off or pick up DNA orders.
  • Core staff will pre-arrange a time and have the DNA orders waiting for the customer to pick up.
  • One customer will be allowed in the office space at a time and customers are required to wear masks while in the Vector Core office.

Virus orders: 

  • Customers will enter our lab office, ring the doorbell located on the desk, and put their ice bucket on the table just inside the main lab (through the internal door from office to lab) and retreat back to the office. 
  • Core personnel will communicate and retrieve/add plasmid or virus preps to/from the ice bucket maintaining social distancing with the customer. 
  • Customers will then retrieve their bucket and leave. 
  • One customer will be allowed in the office space at a time and customers are required to wear masks while in the Vector Core office.

For out-of-building customers:

  • A pre-arranged drop-off/pick-up time will be scheduled. 
  • Once the customers are outside the building, they will call the Vector Core and core staff will take samples (packaged under BSL2 requirements and disinfected) outside the building to make the exchange.
  • Both customers and core personnel are expected to wear masks and practice social distancing. 
  • The exchange will take place where there is an outside table.
  • Customers will be asked ahead of time to put their ice bucket on the table upon arrival and step back.
  • Core personnel will place/retrieve viruses or DNA in/from their ice bucket and leave.
  • Customers will then retrieve their ice bucket.

Thank you all for your patience and cooperation as we take these first steps in reopening research at the University of Michigan. If you have any questions, please contact me at lanigant@umich.edu.