Proteomics Publications

1. S. Gadwal, TL. Johnson, HA. Remmer, M. Sandkvist. C-terminal processing of Gly-Gly CTERM containing peptides by rhombosortase in vobrio cholerae. PLOS Pathogens, accepted for publication.
2. RA. Ohara, HA. Remmer, PL. Campbell, DA. Fox , JH. Ruth. Citrullination of Inhibitor of DNA Binding-1 at Specific Locations Leads to Autoantigenicity in Rheumatoid Arthritis. 2016. Accepted for oral presentation at the ACR/ARHP (American Society for Rheumatology) conference, November 2016, Washington, DC.
3. P. Georgoff, I. Halaweish, V. Nikolian, T. Bonham, H. Remmer, R. Menon, B. Liu, Y. Li, HB. Alam. Alterations in the human proteome following administration of valproic acid. 2016. J. Trauma and Acute Care Surgery, accepted for publication.
4. WR. Swindell, HA. Remmer, MK. Sarker, X. Xing, DH. Barnes, L. Wolterink, JJ. Vorhees, RP. Nair, A. Johnston, JT. Elder, JE. Gudjonsson. Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance.2015. Genome Med. Aug 4;7 (1):86. Doi: 10.1186/s13073-015-0208-5.e Collection 2015.
5. LL. Kubik, RW. Landis, HA Remmer, IL. Bergin, MA. Philbert. 2015. 1,3-dinitrobenzene induces age-and region-specific oxidation to mitochondria –related proteins in brain. Toxicol. Sci. May; 145(1): 48:58. Doi:10.1093/toxsci/kfv015.PMID: 25716674
6. MP. Mendez, SB. Morris, S. Wicoxen, M. Du, YK. Monroy, H. Remmer, H. Murphy, PJ. Christensen. R. Paine III. 2008. Disparate Mechanisms of sICAM-1 production in the peripheral lung: contrast between alveolar epithelial cells and pulmonary microvascular endothelial cells. Am. J. Lung Cell Mol. Physiol. 294, L807-L814. doi: 10.1152/ ajplung. 00389.2007
7. I.J. Goldstein, H.C. Winter, L. Confer, J.T. Adamson, K. Hakansson, H.A. Remmer 2007.A new a-galactosyl-binding protein from mushroom Lyophyllum decastes. Arch. Biochem. Biophys. 467, 268-274. doi: 10.1016/j.abb.2007.08.017.
8. Z.Zhang, H.A. Remmer, D.D.Thomas and C.B. Karim. 2006. Backbone Dynamics Determined by Electron Paramagnetic Resonance to Optimize Solid Phase Peptide Synthesis of TOAC-labeled Phospholamban. Biopolymers Peptide Science, 88 (1) p.29-35. doi: 10.1002/bip.20618.
9. H.A. Remmer, N.P. Ambulos, L.F. Bonewald, J.D. Dougherty, E. Eisenstein, E. Fowler, J. Johnson, A. Khatri, M.O. Lively, N.M. Ritter, and S. Weintraub.2004. Synthetic Peptides as Certified Analytical Standards, in Peptide Revolution: Genomics, Proteomics and Therapeutics (M Chorev and TK. Sawyer, eds), Kluwer Academic Publishers, p. 65-66.
10. M.M.Rosenblatt, D.L. Huffman, X. Wang, H.A.Remmer & K.S. Suslick. 2002. Cyclic and Hairpin Peptide Complexes of Heme. J. Am. Chem. Soc. 124, 12394-12395.
11. K. F.Medzihradszky, N. P. Ambulos, A. Khatri, G. Osapay, H.A. Remmer, A. Somogyi, and S. A. Kates.2002. Mass spectrometry analysis for the determination of side reactions for cyclic peptides prepared from an Fmoc/tBu/Dmab Protecting Group Strategy. Lett. Peptide Sci 8,1-12.
12. Khatri, N.P. Amboulos, S.A. Kates, K.F. Medzihradszky, G. Ösapay, H.A. Remmer and A. Sompgyi Strategies for the synthesis of cyclic peptides. 2001. Peptides: The wave of the future (M Lebl and RA Houghton,eds) Kluwer Academic Publishers, p 140-141.
13. H.A. Remmer_The Peptide Standards Project Committee. 2001. J. Biomoecular Techniques 12, 3,72-73.
14. H.A. Remmer_and G.B. Fields. 1999. Problems encountered with the synthesis of a glycosylated hydroxylysine derivative suitable for Fmoc-solid phase peptide synthesis. In: Peptides: Frontiers of Peptide Science (J.PTam and P.T.P. Kaumaya, eds), Kluwer Academic Publishers, 287-288.
15. H.A. Remmer, E. Jaeger, G.Jung, P. Ruecknagel, T. Abdel-Razek and S.I. Said “Structure Activity Studies on VIP III: Synthesis and properties of [Ser(SO3H)3, Ahx17]VIP, [Ahx17]PACAP-27 and the VIP-PACAP-Hybrid [Ahx17, Ala24, Ala25, Val26]VIP-(1-27)-amide” in: Peptides 1994, Proceedings of the twenty-third European Peptide Symposium (HLS Maia, ed) p. 367-368; Escom 1995
16. H.A. Remmer, E. Jaeger, P. Ruecknagel & G. Jung. 1994. Comparison of Fmoc-solid phase methods for the synthesis of pure [Nle17] VIP. In: Innovation and Perspectives in Solid Phase Synthesis: Peptides, Proteins and Nucleic Acids Biomedical Applications (R. Epton, ed.) Mayflower Worldwide, Birmingham (1994) p. 657-660.
17. E. Jaeger, H.A. Remmer, G. Jung, J. Metzger, W. Oberthuer, K.P. Ruecknagel, W. Schaefer, J. Sonnenbichler & I. Zetl. 1993. Side reactions in peptide synthesis V: “O-Sulfonation of Serine and Threonine during removal of the Pmc- and Mtr-protecting groups from arginine residues in Fmoc solid phase synthesis” Biol. Chem. Hoppe-Seyler, 374 ,349-362.
18. E. Jaeger, P. Ruecknagel, H.A.Remmer & G. Jung. 1993. Synthesis and properties of peptides containing O-sulfonated serine and threonine residues.1993. in Chemistry of Peptides and Proteins Vol. 5/6 (D. Brandenburg, V. Ivanov & W. Voelter, eds.), DWI Reports, Vol. 112A, Verlag Mainz, Aachen, 115-124.
19. E. Jaeger, G. Jung, H.A. Remmer & P. Ruecknagel“ Formation of amino acid O-sulfonates during removal of the Pmc-group from Arginine residues in SPPS” in: Peptides, Chemistry and Biology, Proceedings of the twelfth American Peptide Symposium (J.A. Smith & J. Rivier, eds.), p. 629-630, Escom Scientific Publishers (1992).
20. E. Jaeger, N. Veretennikova, H.A. Remmer & P. Ruecknagel “Synthetic studies on Tuftsin, VIP and gastrin analogs using Fmoc-amino acid-N-carboxyanhydrides in SPPS” in: Peptides 1992 Proceedings of the twenty-second European Peptide Symposium (C.H. Schneider & A.N. Eberle, eds.) p. 226-228; Escom Science Publishers, 1992.
21. E. Jaeger, H.A. Remmer, P. Thamm, S.I. Said & H. Sharaf . 1992. Structure activity studies on Vasoactive intestinal peptide: synthesis of analogs modified at residues Asp3-Ala4 and Asn9. Regulatory Peptides 40, 175.
22. H.A. Remmer, G. Jung, P. Ruecknagel & E. Jaeger “Facile formation of 2,3-didehydroalanine and 2,3-didehydrobutyrine in peptides containing O-sulfonated serine and threonine residues” in: Peptides 1992, Proceedings of the twenty-second European Peptide Symposium (C.H. Schneider & A.N. Eberle, eds.) p. 167-168; Escom Science Publishers,1992.

Book Chapter

1. H.A. Remmer and G.B. Fields 2000. Chemical synthesis of peptides. In: Peptides and Protein Drug Analysis (Ronald E. Reid, ed), p. 133-169, Marcel Dekker Inc, New York.

(selected publications without authorship)

S.M. Rizvi, L. Mancino, V. Thammavongsa, R.L. Cantley, M. Raghavan. 2004. A polypeptide binding conformation of calreticulin is induced by heat shock, calcium depletion, or by deletion of the C-terminal acidic region. Molecular Cell, 15 (6), pp. 913-923. doi: 10.1016/j.molcel.2004.09.001
J.-F. Couture, E. Collazo, J.S. Brunzelle, RC Trievel. 2005. Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev. June 15; 19(12): 1455–1465. PMCID: PMC1151662. doi: 10.1101/gad.1318405.
V. Thammavongsa, L. Mancino, M. Raghavan. 2005. Polypeptide Substrate Recognition by Calnexin Requires Specific Conformations of the Calnexin Protein. J. Biol. Chem. 280, 33497–33505 PMID: 16061483. doi:10.1074/jbc.M503648200.
J.H. Kurzer, P. Saharinen, O. Silvennoinen, C. Carter-Su. 2006. Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state. Mol Cell Biol 26: 6381–6394, 2006. PMCID: PMC1592834. doi: 10.1128/MCB.00570-06.
S. Ling, A. Lai, O. Borschukova, P. Pumpens, J. Holoshitz. 2006. Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope. Arthritis Rheum. Nov; 54 (11): 3423-32.
V. Thammavongsa, G. Raghuraman, T. M. Filzen, K. L. Collins, M. Raghavan. 2006. HLA-B44 polymorphisms at position 116 of the heavy chain influence TAP complex binding via an effect on peptide occupancy. J. Immunol.177, 3150–3161. PMID: 16920953.
S. M. Rizvi, M. Raghavan. 2006. Direct peptide-regulatable interactions between MHC class I molecules and tapasin. Proc. Natl. Acad. Sci. USA 103: 18220–18225. PMID: 17116884. doi: 10.1073/pnas.0605131103.
S.Ling, X. Pi, J. Holoshitz. 2007. The rheumatoid arthritis shared epitope triggers innate immune signaling via cell surface calreticulin. J Immunol.179:6359–6367. [PubMed: 17947714]
S. Ling, Z. Li, O. Borschukova L. Xiao, P. Pumpens and J. Holoshitz. 2007. The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing anadenosine-mediated anti-oxidative pathway. Arthritis Research & Therapy , 9:R5 (doi:10.1186/ar2111)
Holoshitz J, Ling S. 2007. Nitric oxide signaling triggered by the rheumatoid arthritis shared epitope: a new paradigm for MHC disease association? Ann N Y Acad Sci. 1110:73–83. [PubMed: 17911422]
R. Nichols. 2007. The first nonsulfated sulfakinin activity reported suggests nsDSK acts in gut biology. Peptides;28:767–73. PMID: 17292511. doi: 10.1016/j.peptides.2007.01.009.
G.C. Palmer, T. Tran, A. Duttlinger, R. Nichols. 2007. The drosulfakinin 0 (DSK 0) peptide encoded in the conserved Dsk gene affects adult Drosophila melanogaster crop contractions. J Insect Physiol. 53:1125–1133. PMID: 17632121. doi: 10.1016/j.jinsphys.2007.06.001.
Huang C, Yoshino-Koh K, Tesmer JJG. 2009. A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases. J. Biol. Chem. 2009, 284:17206-15. doi: 10.1074/jbc.M809544200 PMID: 19364770.
P. Yang, Y. Mao, A.W.-M. Lee, R.T. Kennedy. 2009. Measurement of Dissociation Rate of Biomolecular Complexes Using Capillary Electrophoresis. Electrophoresis, February; 30(3): 457–464. doi: 10.1002/elps.200800397; PMID: 19148904
V. Thammavongsa, M. Schaefer, T. Filzen, K.L. Collins, M. Carrington, N. Bangia, M. Raghavan. 2009. Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503. Immunogenetics 61:703–716. PMID: 19838694. doi: 10.1007/s00251-009-0399-2.
S.J. Segvich, H.C. Smith, D.H. Kohn. 2009. The adsorption of preferential binding peptides to apatite-based materials. Biomaterials, 30 (7), pp. 1287–1298. PMID: 19095299. doi: 10.1016/j.biomaterials.2008.11.008
SA Robertson, RI Koleva, LS Argetsinger, C Carter-Su, JA Marto, EP Feener, MG Meyers Jr. 2009.Regulatoin of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling. Mol. Cell Biol. Jun; 29(12);3367-3378. PMID:19364823 PMCID: PMC2698725; doi: 10.1128/MCB.00278-09
H. Yao, D.M. Veine, Z.Z. Zeng, K.S. Fay, E.D. Staszewski, D.L. Livant. 2010. Increased potency of the PHSCN dendrimer as an inhibitor of human prostate cancer cell invasion, extravasation, and lung colony formation. Clin. Exp. Metastasis 27:173–184. PMID: 20339907. doi: 10.1007/s10585-010-9316-1.
C.G. Besirli, N.D. Chinskey, Q.-D. Zheng, D.N. Zacks. Inhibition of retinal detachment–induced apoptosis in photoreceptors by a small peptide inhibitor of the Fas receptor. Invest Ophthalmol. Vis Sci. 2010;51(4):2177–2184. PMCID: PMC2868404. doi: 10.1167/iovs.09-4439.
P. Kamarajan, A. Garcia-Pardo, N.D’Silva, Y Kapila. 2010. The CS1 segment of fibronectin isinvolved in human OSCC pathogenesis by mediating OSCC cell spreading, migration, and invasion BMC Cancer 2010, 10:330; doi: 10.1186/1471-2407-10-330; PMID: 20579373.
S. Ling, A. Cheng, P. Pumpens, M. Michalak, J. Holoshitz. 2010. Identification of the Rheumatoid Arthritis Shared Epitope Binding Site on Calreticulin. PLoS ONE 5(7): e11703. doi:10.1371/journal.pone.0011703
D. E. De Almeida, S. Ling, X. Pi*, A. M. Hartmann-Scruggs, P. Pumpens, and J.Holoshitz. 2010. Immune Dysregulation by the rheumatoid shared epitope. J Immunol. August 1; 185(3): 1927–1934. doi:10.4049/jimmunol.0904002; PMID: 20592276
P.A. DelRizzo, J.-F. Couture, L.M.A. Dirk, B.S. Strunk, M.S. Roiko, J.S. Brunzelle, R.L. Houtz, R.C. Trievel. 2010. SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation J. Biol. Chem. 285 (41):31849-31858. PMCID: PMC2951256. doi: 10.1074/jbc.M110.114587
LS Argetsinger, JA Stuckey, SR Robertson, RI Koleva, JM Cline, JA Marto, MG Myers Jr, C. Carter-Su. 2010. Tyrosines 868, 966 and 972 in the kinase domain of Jak2 are autophosphorylated and required for maximal Jak2 kinase activity. Mol. Endocrinol. 2010 Mar 19 PMID: 20304997.
H. Yao, D.M. Veine, K. Fay, E. Staszewski, Z.Z. Zeng, D. Livant. 2011. The PHSCN dendrimer as a more potent inhibitor of human breast cancer cell invasion, extravasation, and lung colony formation. Breast Cancer Res Treat. ;125:363–375. PMID: 20300829. doi: 10.1007/s10585-010-9316-1.
N. Gupta and S.W. Ragsdale. 2011. Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor Rev-erb. J. Biological Chem. 286 (6): 4392-4403. Doi: 10.1074/jbc.M110.193466; PMID: 21123168.